CD Markers

24669 Views 21 Replies 16 Participants Last post by dysdiadochokines, Dec 29, 2016

HouseWannabe

Discussion Starter · Dec 14, 2009

I've come across a lot of questions in UW that required knowledge of CD markers, see if you can id these ones: (Location/what they're markers for/ and if they're used for any specific type of Leukemia)

1. CD2
2. CD3
3. CD4
4. CD8
5. CD10
6. CD16
7. CD19
8. CD20
9. CD21
10. CD56
11. TCR

Reactions: 5

1 - 20 of 22 Posts

khanar

· #2 · Dec 14, 2009

CD 16, 56 present on Natural Killer cells
CD 14 present on phagocytes
CD 10 present on leukemic T cells in ALL
CD 19,20,21 on B lymphocytes (21 is attachment of EBV)
CD 2,3 on T lymphocytes (muromonab blocks CD3 used in allograft rejection)
TCR on T lymphocytes closely associated with CD2 and CD3

Reactions: 5

DrLANC

· #3 · Dec 14, 2009

Missed one!

Hey friend, you missed another important one.

CD18 - the absence of it causes Leukocyte adhesion deficiency

Reactions: 5

khanar

· #4 · Dec 14, 2009

CD55 and CD59

Speaking of CD receptors

Do you know what's CD55 and CD59

Reactions: 4

tima

· #5 · Dec 15, 2009

Do you know what's CD55 and CD59

When CD 55 and 59 are deficient you will end up with Paroxysmal nocturnal Hemoglobinuria, which are cell surface protein that help inactivate complement!

Reactions: 5

khanar

· #6 · Dec 15, 2009

tima said:
When CD 55 and 59 are deficient you will end up with Paroxysmal nocturnal Hemoglobinuria, which are cell surface protein that help inactivate complement!

Correct

Reactions: 1

khanar

· #7 · Dec 15, 2009

Also check this
http://www.usmle-forums.com/usmle-step-1-forum/937-cd43-versus-cd34.html

Reactions: 2

DrSeddik

· #8 · Dec 15, 2009 (Edited)

CD 1a- histiocytosis x
CD 5- mantle cell lymphpma, SLL/CLL
CD 2- only one present in all T-lymphocyte lineage including NKC
CD 31-(PECAM-1) Liver angiosarcoma

Reactions: 4

HouseWannabe

Discussion Starter · #9 · Dec 15, 2009

Glad this thread is helpful; here's a couple more to add to the list:

CD 21: Receptor for the c3d component of complement and EBV .
CD 34: Early lymphohematopoeitic stem cell and progenator cell and function for cell- to- cell adhesion

Some extra info to add on what has already been said:

1. CD2--> Associated with T-antigen receptor/ "LFA2"
2. CD3--> Signal transduction complement of T-cells
3. CD4--> Found on all Helper T-lymphocytes
4. CD8--> Found on all Cytotoxic T-lymphocytes
5. CD10--> CALLA (Common Acute Lymphoblastic Leukemia Antigen) Functions as a metalloendopeptidase (Zn dep)/ Deactivated by chellators
6. CD16--> Fc receptor involved in binding to immune complexes and promoting antibody-dep cell mediated cytotoxicity. (NK cells)
7. CD19--> Is positive at the pro- B-cell stage/ MHC II antigens
8. CD20--> positive in a pro-B-cell
9. CD21--> As well as CD 19, form a receptor complex during B-cell activation.
10. CD56--> Marker for NK cells
11. TCR --> is positive once the T-cell has left the Bone marrow

Some things to watch out for:

12. Mature B-cell--> "naive" Will show both IgM and IgD
13. Mature T-cell--> will either be CD4 or CD8 not both
14. MHC I is stabilized by CD8
15. MHC II is stabilized by CD4 (Pro-cell stage)
16. immature T-cell is NEITHER CD4 nor CD8

I'll try to post a chart of what you see at each B-cell and T-cell stage as markers later on, and please add to the list if you have extra info.

See less See more

Reactions: 5

allergydoctr

· #10 · Oct 3, 2010

cd3 marker tip

cd3 is a T cell marker required for TCR expression and signal transduction. It is NOT found on B cells or NK cells

Reactions: 4

allergydoctr

· #11 · Oct 3, 2010

CD 5

Most B cell markers in CLL are CD 5

Reactions: 3

shafff111

· #12 · Nov 1, 2011

Cd 23

Found on B-Cell,
Differentiate SLL/CLL (CD23+) vs. mantle cell lymphoma or MALT lymphoma (CD23-)

Reactions: 3

bronchiole

· #13 · Nov 2, 2011

HouseWannabe said:
Glad this thread is helpful; here's a couple more to add to the list:

CD 21: Receptor for the c3d component of complement and EBV .
CD 34: Early lymphohematopoeitic stem cell and progenator cell and function for cell- to- cell adhesion

Some extra info to add on what has already been said:

1. CD2--> Associated with T-antigen receptor/ "LFA2"
2. CD3--> Signal transduction complement of T-cells
3. CD4--> Found on all Helper T-lymphocytes
4. CD8--> Found on all Cytotoxic T-lymphocytes
5. CD10--> CALLA (Common Acute Lymphoblastic Leukemia Antigen) Functions as a metalloendopeptidase (Zn dep)/ Deactivated by chellators
6. CD16--> Fc receptor involved in binding to immune complexes and promoting antibody-dep cell mediated cytotoxicity. (NK cells)
7. CD19--> Is positive at the pro- B-cell stage/ MHC II antigens
8. CD20--> positive in a pro-B-cell
9. CD21--> As well as CD 19, form a receptor complex during B-cell activation.
10. CD56--> Marker for NK cells
11. TCR --> is positive once the T-cell has left the Bone marrow

Some things to watch out for:

12. Mature B-cell--> "naive" Will show both IgM and IgD
13. Mature T-cell--> will either be CD4 or CD8 not both
14. MHC I is stabilized by CD8
15. MHC II is stabilized by CD4 (Pro-cell stage)
16. immature T-cell is NEITHER CD4 nor CD8

job well done boss!!!finish it please.

Reactions: 4

Hope2Pass

· #14 · Apr 12, 2012

This is a great thread! I was getting confused on so many CD Markers but this thread helps a lot in narrowing down which ones we need to know!

Thank you!

Reactions: 2

step12345

· #15 · Apr 16, 2012

Thanks. There is a lot of good stuff in this thread.

Reactions: 1

Valkoff

· #16 · Apr 17, 2012

Hope2Pass said:
This is a great thread! I was getting confused on so many CD Markers but this thread helps a lot in narrowing down which ones we need to know!

Thank you!

Thanks for bumping it up. I would have probably missed it.

Reactions: 2

preeti617

· #17 · Oct 24, 2012

I am confused about the differentiation of TH cells. The TH cells are CD4 cells ie they will attach only to the MHCII receptors. Then how do they differentiate into the two types of helper cells? how are the cytokines produced to stimulate the conversion of TH cell to TH1 or TH2?

Reactions: 1

koolkiller88

· #18 · Oct 24, 2012

1. CD2????
2. CD3????
3. CD4- T helper cell
4. CD8- Cytotoxic T cell
5. CD10
6. CD16- NK cells
7. CD19
8. CD20 CD 19, 20,21- B cell
9. CD21
10. CD56- NK cells
11. TCR - Tcell
12. CD 1- langerhans cell

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Reactions: 1

Vaheh

· #19 · Oct 27, 2012

CD15,30 - RS cells in Hodgkin's Lymphoma

Reactions: 2

didia

· #20 · Jul 21, 2016

This is a great thread. Thank you everyone. I will add more if i come across any that haven't been covered so far.

Reactions: 1

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