A 7-year-old girl develops a fever, conjunctivitis, photophobia, and a cough. Her pediatrician notes white spots on a bright red background on the girl's buccal mucosa. Within days, a rash begins around the hairline, then spreads to the trunk and extremities. One week later, the child suddenly begins to convulse, and loses consciousness. She is taken to the emergency room, where involuntary movements and pupillary abnormalities are noted. Which of the following would most likely be seen on CNS biopsy?
A. Demyelination of white matter of cerebral hemispheres with abnormal giant oligodendrocytes
B. Perivenous microglial encephalitis with demyelination
C. Phagocytosis of motor neurons in the spinal cord
D. Severe hemorrhagic and necrotizing encephalitis of the temporal lobe with eosinophilic Cowdry type A
inclusion in neurons and glia
E. Small granulomas with central caseation in the meninges
A. Demyelination of white matter of cerebral hemispheres with abnormal giant oligodendrocytes
B. Perivenous microglial encephalitis with demyelination
C. Phagocytosis of motor neurons in the spinal cord
D. Severe hemorrhagic and necrotizing encephalitis of the temporal lobe with eosinophilic Cowdry type A
inclusion in neurons and glia
E. Small granulomas with central caseation in the meninges