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Colon CA and Renal Disease

5035 Views 5 Replies 5 Participants Last post by  aktorque
A 56-year-old Caucasian male who was recently diagnosed with colon cancer suffers from generalized edema. Urine protein excretion is 4.5g over 24 hours. Kidney biopsy shows glomerular capillary wall thickening without an increase in cellularity. When the sample is stained with silver methenamine, irregular spikes protruding from glomerular basement membrane are seen. This patient most likely suffers from which of the following?

A. Anti-SBM disease
B. ANCA-associated glomerulonephritis
C. Membranous glomerulopathy
D. Membranoproliferative glomerulonephritis
E. Postinfectious glomerulonephritis
F. Berger disease
G. Focal segmental glomerulosclerosis
H. Minimal change disease
I. Alport syndrome
J. Thin basement membrane syndrome
K. Amyloidosis
L. Multiple myeloma
M. Malignant hypertension
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Answer is C.

Nephrotic Syndrome caused by membranous glumerolopathy. Most cases are idiopathic, some are caused by drugs such as pencillamine, gold,; some by neoplasms such as lymphoma, colon cancer.....
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