[lemontea88]

Am I correct to say that corticosteroids will increase the total WBC count because of the neutrophil being demarginated from the vessel wall?

But then is it also right to say that corticosteroids will decrease Lyphocyte count and also Eosinophil count?

So my question is does this mean that the increase in neutrophil count far outweigh the decrease in lymphocyte and eosiniphil count?

 

[Sabio]

Yes you are right
Corticosteroids blocks the egress of leukocytes from the circulation to the tissues (one of the mechanisms by which corticosteroids act as immunosuppressive).
At the same time it cause a decrease in lymphocytes counts (specifically T lymphocytes) which is another mechanism of immunosuppression of CTS.
However, the decrease in lymphocytes is in the percentage and not in the absolute count and therefore it's called relative lymphopenia.
The leukocytosis effect usually occurs faster than the relative lymphopenia.