Rather, it decreases number and activity of osteoblasts.Hi guys! Can anyone explain me how cortisol decreases bone formation?does it increase the activity of osteoclasts?
Endocrinologic conditions or medications that lead to bone loss (eg, glucocorticoids) can cause osteoporosis. Corticosteroids inhibit osteoblast function and enhance osteoblast apoptosis...
Doesn't really answer the question though...Hypercortisolism is the Secondary cause of osteoporosis (which is most common metabolic abnormality of bone)(2) Decreased thickness of cortical and trabecular bone
Loss of both organic bone matrix and minerals
(1) Decreased bone mass and density
• Radiograph shows osteopenia (washed out appearance).
(a) MosT common type (80% women. 60% men)
(b) Idiopathic type in children and young adults
(c) Postmenopausal type (most common)
(d) Senile type in men andwomen
(a) Underlying disease (e.g., hypercortisolism)
(b) Drugs (e.g.. heparin)
(e) Hypogonadism (e.g.. hypopituitarism)
(d) Malnutrition (e.g.. anorexia nervosa)
(c) Space travel (Lack of gravity reduces bone stress).
Hope this helps
Are you sure cortisol causes lipogenesis? i thought i causes LIPOLYSIS ?This is just a quick review I have of the effects of cortisol on body, some of which I think is helpful for step 1:
Cardiovascular System-->upregulates alpha 1--> hypertension
Collage- Reduce collagen synthesis- striae
Bone- inhibit osteoblastic activity
Intestines- reduce calcium reabsorption
Kidney- increase calcium release
Important for fetal lung maturation : surfactant
Increases lipogenesis- increasing truncal obesity
Causes insulin resistance and increases gluconeogensis
Inhibits Arachidonic acid breakdown-->specifically PLA2 enzyme leading to reduction on inflammatory response
Increases in ulceration and gastric acid production due to inhibition of prostaglandin PGI2--> protective agent for gastric ulceration.
Cortisol like ALL other stress hormones does cause lipolysis. It increases the fat i nthe body hence in cushing we see the buffalo hump.r u sure cortisol causes lipogenesis? i thought i causes LIPOLYSIS ?