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This is a topic loved by USMLE question makers although it's rather uncommon condition.
What we need to know about cryglobulinemia for the purpose of USMLE Step 2 CK is this:
Cryoglobulins:
Proteins that turn insoluble at lower body temperatures.
Causes:
Hepatitis B and C.
Mycoplasma.
Multiple Myeloma and Waldenstrom Macroglobulinemia
SLE and RA
Clinical features:
Meltzer's Triad = Arthralgia, Myalgia, and Purpuric rashes.
ESR is high, RF may be positive, Complement is low
Treatment:
Management of the underlying cause and sometimes plasmapheresis is needed.
What we need to know about cryglobulinemia for the purpose of USMLE Step 2 CK is this:
Cryoglobulins:
Proteins that turn insoluble at lower body temperatures.
Causes:
Hepatitis B and C.
Mycoplasma.
Multiple Myeloma and Waldenstrom Macroglobulinemia
SLE and RA
Clinical features:
Meltzer's Triad = Arthralgia, Myalgia, and Purpuric rashes.
ESR is high, RF may be positive, Complement is low
Treatment:
Management of the underlying cause and sometimes plasmapheresis is needed.
