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Hello everyone.
During my study, I noticed that most CYP3A4 inhibitors were antimicrobial, anti fungal drugs, or simply anti-something; which ended up inhibiting the cytochrome enzyme 3A4 in their mechanism of action (MoA).

Just to give a few examples; Ketoconazole, Fluconazole, Chloramphenicol, Erythromycin, Voriconazole, Sulphonamides, Isoniazid, etc...

However, when it comes to NNRTI's for treatment of HIV, most of them are inducers; Nevirapine, Efavirenz (only does this in vivo; inhibits in vitro), Etravirine.

Anyone who knows why and can explain will be greatly appreciated. :) :)

I'd love to know why, so that I don't have to just cram notes without understanding.

Thanks in advance!
 
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