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Discussion Starter · #1 ·
Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation
 

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Discussion Starter · #5 ·
hmmm sorry i didnt understand the explanation there and i forgot in which document the questions was its in either micro2 or 3 from the files u sent
 

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hmmm sorry i didnt understand the explanation there and i forgot in which document the questions was its in either micro2 or 3 from the files u sent
ok no worries. ill go look for it tonight n post it up. this is a shocker question n answer btw.:eek:
 

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Discussion Starter · #7 ·
heyy i found it

Contact with infected secretions such as saliva can result in infection with EBV, thus the term kissing disease. Laboratory diagnosis of EBV-induced infectious mononucleosis is usually determined by presence of atypical lymphocytes, heterophile antibodies, or specific antiviral antibodies such as VCA (viral capsid antibody).
 

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heyy i found it

Contact with infected secretions such as saliva can result in infection with EBV, thus the term kissing disease. Laboratory diagnosis of EBV-induced infectious mononucleosis is usually determined by presence of atypical lymphocytes, heterophile antibodies, or specific antiviral antibodies such as VCA (viral capsid antibody).
but the explanation points to A or C. they said it is B?:confused:
 

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monospot test (heterophile antibodies) can also be positive in people with lymphoma, systemic lupus erythematosus (lupus), and some gastrointestinal cancers, although it is not used as a diagnostic or screening tool for these conditions. negative monospot test with same clinical scenario as EBV suggests CMV...
 

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the article talks about IgM specific for EBV. n that is what a heterophile antibody is. i understand how atypical lymphocytes also points towards kissing disease, but in kaplan, the diagnosis of kissing disease is made by finding of heterophile antibody finding. atypical lymphocytes is not specific.
 

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@seetal thats y i answered it as C

any seniors who can clear this doubt
thanks in advance
i also leaned towards C at the instant i read the question, bkz all qbanks wen ask such a question they point towards heterophile antibodies, then i googled up so find this article... so i thot ok A is the answer... now its confusing really:notsure:
 
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Discussion Starter · #19 ·
actually it is confusing but most of the question banks they refer to heterophile antibodies so lets go with that answer
 

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actually it is confusing but most of the question banks they refer to heterophile antibodies so lets go with that answer
lol... u know guys, what's important is that we now know what's the FOR SURE answer. so whether it's A or C, they wont repeat this same question for out Exam, but at least we know if they ask heterophile positive we say mono, if they ask heterophile negative we say CMV. :))
 
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