Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation