A 52-year-old woman dies 9 months after being diagnosed with well-differentiated ductal carcinoma of the right breast metastatic to the brain, liver, and lung. Her mother and one of her sisters have also died from beast carcinoma. Which of the following molecular abnormalities is most likely to be found in this patient?
A- Amplification of the HER2 gene in somatic cells
B- Amplification of the n-myc gene in neoplastic cells
C- Deletion of the Rb locus in health somatic cells
D- Fusion of the ABR and C-ABL genes in neoplastic cells
E- Germline inactivation of the BRCA-1 gene
A- Amplification of the HER2 gene in somatic cells
B- Amplification of the n-myc gene in neoplastic cells
C- Deletion of the Rb locus in health somatic cells
D- Fusion of the ABR and C-ABL genes in neoplastic cells
E- Germline inactivation of the BRCA-1 gene