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I have a question about Corynebacterium Diptheriae... Does anyone know what a beta prophage is? I know a phage in general is viral DNA thats integrated into a bacterial genome. Here though, I was taught to associate C. Diptheriae with beta prophage and I don't know what that means - any ideas?
 

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Well i am not confident about my micro ... Anyways i will try to explain :eek:

Corynebacterium Diphtheria cause disease by production of diphtheria toxin. This exotoxin inhibits protein synthesis via ADP-ribosylation of EF-2.
Not all strains of C. diphtheria are pathogenic. Remember some C. diphtheria are also member of our normal flora.

Gene for toxin production is located on the DNA of the Beta phage. So when C. diphtheria are infected by this beta prophage, they acquire the ability to produce the toxin and become pathogenic.

I think thats the reason why these two are associated...
 
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