[lemontea88]

What exactly does these sentence from First Aid mean?

(Under HBV)
"Cellular RNA polyerase transcribes RNA from DNA template. Reverse transcriptase transcribes DNA genome from RNA intermediate. However, the virion enzyme is a DNA-dependent DNA polymerase."

Okay, the first sentence (correct me if I am wrong) means that our cell's RNA polymerase makes RNA from HBV's DNA. The 2nd sentence means that HBV has reverse transcriptase that makes back its DNA from the RNA that our RNA polymerase has just made?

What would the 3rd sentence mean? Has it got any relation with the fact that HBV can incorprate its DNA into our cells?

 

[lemontea88]

So does that mean DNA-dependent DNA polymerase is actually another additional enzyme (which means HBV got 2 enzyme which is reverse transcriptase and this DNA-dependent DNA polymerase),

or does that mean our liver cell's RNA polymerase and HBV's reverse transcriptase are collectively called "DNA-dependent DNA polymerase, because RNA polymerase change DNA to RNA, and reverse transcriptase change RNA back to DNA?

 

[lemontea88]

Ahh, I see! Thanks Sabio for the explanation

But one question though,

HBV does not integrate it's genome into the host DNA, it stays episomal.

View attachment 407

I always thought the mechanism by which HBV can cause Hepatocellular carcinoma is by integrating its DNA into hepatocyte's DNA. Am I wrong or have I misunderstood you sentence?