I was going over concepts, and came across this question. May be USMLE will not ask this directly, but I think concept is important, especially for the first reading.By the way, where are you readingthis is not high yield for the USMLE
Yeah, this is a low yield concept and you should not waste your time with it.I was going over concepts, and came across this question. May be USMLE will not ask this directly, but I think concept is important, especially for the first reading.
The non-ionized will cross and then it will be ionized inside the cell (by the intracellular PH, depending if it was weak acid or base)Thanks for the explanation. But if an ionized drug does not cross membrane, it will accumulate outside of cell and will increase extracelluar concentration. I am still a little confused.