USMLE Forums banner
1 - 12 of 12 Posts
G

·
PPI is the answer

As far as I know that PPI are associated with SBP (spontaneous bacterial peritonitis) this in turn may precipitate hepatic encephalopathy.
 

·
Registered
Joined
·
57 Posts
Colchine used in gout ..
Its true PPI may worsen SBP .... Thanks for that coz i forgot that ..
But its not PPI ....
How about frusemide ?
IS that the drug which can coz changes in K level in bloob ?
I think changes in K level in blood could precipitate encephalopathy.
 

·
Registered
Joined
·
4,342 Posts
More ammonia in alkalosis

What is the mechanism by which hypokalemia causes hepatic encephalopathy!?
The hypokalemia and metabolic alkalosis seen with any diuretic therapy (except K+ sparing) will favor the conversion of NH4+ to NH3 thereby contributing to more ammonia formation and worsening or precipitating the encephalopathy.
 
G

·
woow

The hypokalemia and metabolic alkalosis seen with any diuretic therapy (except K+ sparing) will favor the conversion of NH4+ to NH3 thereby contributing to more ammonia formation and worsening or precipitating the encephalopathy.
Woow, thank you for the explanation
 

·
Registered
Joined
·
247 Posts
Discussion Starter · #12 ·
Dehydration , infection , electrolyte abnormality ( decre.K+ & increa HCO3-), sedative , GI bleeding = all of this condition worsen encephalopathy ...
In cirrhosis diuretics is used for edema and ascitis , so if it used excessively for edema ,it may cause dehydration and elec abnormality which worsen encephalopathy .......
 
1 - 12 of 12 Posts
Top