[FSUSTC]

Excessive use of which drug may precipitate hepatic encephalopathy and why ..
a. Metoprolol
b. enalapril
c. furosemide
d. cholcine
e . PPI

 

[Ryuunosuke]

PPI is the answer

As far as I know that PPI are associated with SBP (spontaneous bacterial peritonitis) this in turn may precipitate hepatic encephalopathy.

 

[Ryuunosuke]

cholcine?

What is chocine by the way?

 

[FSUSTC]

Colchine used in gout ..
Its true PPI may worsen SBP .... Thanks for that coz i forgot that ..
But its not PPI ....

 

[Ryuunosuke]

Colchine used in gout ..
Its true PPI may worsen SBP .... Thanks for that coz i forgot that ..
But its not PPI ....

So you mean Colchicine not colchine
If PPI is not the answer then what is it? Please tell me

 

[FSUSTC]

sorry for that .. yes its colchicine
Ans is furosemide ....but Why ??

 

[Ryuunosuke]

sorry for that .. yes its colchicine
Ans is furosemide ....but Why ??

Really I don't know, that's a good question. Let's see if somebody can answer it for us here

 

[wahaha007]

Colchine used in gout ..
Its true PPI may worsen SBP .... Thanks for that coz i forgot that ..
But its not PPI ....

How about frusemide ?
IS that the drug which can coz changes in K level in bloob ?
I think changes in K level in blood could precipitate encephalopathy.

 

[Ryuunosuke]

How about frusemide ?
IS that the drug which can coz changes in K level in bloob ?
I think changes in K level in blood could precipitate encephalopathy.

What is the mechanism by which hypokalemia causes hepatic encephalopathy!?

 

[khanar]

More ammonia in alkalosis

What is the mechanism by which hypokalemia causes hepatic encephalopathy!?

The hypokalemia and metabolic alkalosis seen with any diuretic therapy (except K+ sparing) will favor the conversion of NH4+ to NH3 thereby contributing to more ammonia formation and worsening or precipitating the encephalopathy.

 

[Ryuunosuke]

woow

The hypokalemia and metabolic alkalosis seen with any diuretic therapy (except K+ sparing) will favor the conversion of NH4+ to NH3 thereby contributing to more ammonia formation and worsening or precipitating the encephalopathy.

Woow, thank you for the explanation

 

[FSUSTC]

Dehydration , infection , electrolyte abnormality ( decre.K+ & increa HCO3-), sedative , GI bleeding = all of this condition worsen encephalopathy ...
In cirrhosis diuretics is used for edema and ascitis , so if it used excessively for edema ,it may cause dehydration and elec abnormality which worsen encephalopathy .......