A 15-month-old girl is referred for ophthalmologic and neurologic follow-up by her pediatrician. The child has shown a failure to thrive, is microcephalic, exhibits myoclonic jerks, delayed psychomotor development, visual disturbance and seizures. Analysis of fibroblasts from the skin by electron microscopy confirms the presence of fingerprint inclusion bodies. Elevated levels of dolichol are found in the urine. Normally, dolichol is associated with which cellular process:
A. Sulfation in the trans compartment of the Golgi
B. O-linked glycosylation in the medial compartment of the Golgi
C. O-linked glycosylation in the cis compartement of the Golgi
D. N-linked glycosylation in the endoplasmatic reticulum
E. Sorting of proteins to the lysosome from the TGN
A. Sulfation in the trans compartment of the Golgi
B. O-linked glycosylation in the medial compartment of the Golgi
C. O-linked glycosylation in the cis compartement of the Golgi
D. N-linked glycosylation in the endoplasmatic reticulum
E. Sorting of proteins to the lysosome from the TGN