I whole heartedly agreeE is correct.Pyruvate dehydrogenase catalyzes the irreversible conversion of pyruvate to acetyl-CoA. If it's absent, pyruvate will be used in other pathways instead. Pyruvate
will be converted to alanine via alanine aminotransferase and to lactate via lactate
pyruvate will be increased with concomitant increase in lactic acid and alanine via transamination and severe reduction in ATP production.Then u have lactic acidosis , neurologic defects...