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E is correct.Pyruvate dehydrogenase catalyzes the irreversible conversion of pyruvate to acetyl-CoA. If it's absent, pyruvate will be used in other pathways instead. Pyruvate
will be converted to alanine via alanine aminotransferase and to lactate via lactate
dehydrogenase .
pyruvate will be increased with concomitant increase in lactic acid and alanine via transamination and severe reduction in ATP production.Then u have lactic acidosis , neurologic defects...
I whole heartedly agree
 
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