[lee-usmle]

There are three types of estrogens in the human female body and the boards usually likes to tease us with these various types.

Here's a quick encounter about these three hormones that should be enough for USMLE prep:

Estradiol: Is the young female's hormone of femininity. It's also called E2. It's prododuced by aromatization of Testosterone in the Graafian follicle (granulosa cell). It's the most potent estrogen with the highest effect on receptors.

Estrone: Is the estrogen of the menopause. It's produced by aromatization of androstenedione in peripheral (fatty) tissue. It's also called E1. It's less potent than Estradiol.

Estriol: Is the placental estrogen and it's only seen during pregnancy and it's high levels reflects fetal well being. It's also called E3. It's the least potent of all estrogens. It originates from the fetal adrenal gland in the form of DHEA Sulfate and then is finally transformed to Estriol in the placenta by the sulfatase enzyme.

 

[dr_ram]

mnemonic

this sounds funny, but an easy one...

1. Estr'ONE' = E1 = appears when menstual cycles are g'ONE'.

2. Estra'DI'ol = E2 = peaks 'D'uring 'I'ntermenstrual period.

3. Es'TRI'ol = E3 = appears during the 'TRI'mesters of pregnancy.

 

[kaymax]

thank u so much esp 4 d mnemonic..this marks d end of alota confusion 4 me!

 

[doxorubicin]

u can remember order of appearance as


A estrAdiol reproductive yrs
I estrIol pregnancy
O estrOne postmenopause

 

[gear2d]

Sources of Estrogen

So doing reproduction in FA and needed helping making sure I had this down in terms where three types of estrogen are made:

Male
Estrone - Adipose

Estradiol - Sertoli Cells

Estriol - none

Female

Estrone - Adipose and Ovaries

Estradiol - Granulosa cells and Placenta

Estriol - Placenta

 

[mbbs2010]

So doing reproduction in FA and needed helping making sure I had this down in terms where three types of estrogen are made:

Male
Estrone - Adipose

Estradiol - Sertoli Cells

Estriol - none

Female

Estrone - Adipose and Ovaries

Estradiol - Granulosa cells and Placenta

Estriol - Placenta

Yup! Corrects...

But the thing for estriol in females is although first aid says placenta... Other books say fetus..

Anyhow it's a direct monitoring parameter of fetal well being

 

[sanjana bhimani]

thank you guys for sharing, its really helpful

 

[purvesh1991]

thank you guys.

 

[Kimmie]

Yup! Corrects...

But the thing for estriol in females is although first aid says placenta... Other books say fetus..

Anyhow it's a direct monitoring parameter of fetal well being

During pregnancy, estrogen is synthesised by the feto-placental unit. The fetal adrenal gland secretes androgen precursor, and the placenta aromatizes it to estriol which is released into maternal circulation

 

[TitanEsXVI]

Thanks for the explanations guys, it helped me a lot