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in the first aid book, the diagram shows that gemfibrozil stimulates lipoprotein lipase, which would break down VLDL to IDL, but how would that reduce cholesterol?
thanks
thanks
without lipoprotein lipase (LPL), the adipose tissue cannot take up chylomicrons. cholesterol esters (not cholesterol) are absorbed from the intestine n packaged in chylomicrons, then the LPL (at adipose tissue) hydrolyzes this complex to form chylomicron remnant, which is taken to the liver, then back out again as VLDL (which now carries cholesterol).in the first aid book, the diagram shows that gemfibrozil stimulates lipoprotein lipase, which would break down VLDL to IDL, but how would that reduce cholesterol?
thanks
what is the difference between esterified cholesterol (on chylomicron) and just cholesterol (on VLDL) ?without lipoprotein lipase (LPL), the adipose tissue cannot take up chylomicrons. cholesterol esters (not cholesterol) are absorbed from the intestine n packaged in chylomicrons, then the LPL (at adipose tissue) hydrolyzes this complex to form chylomicron remnant, which is taken to the liver, then back out again as VLDL (which now carries cholesterol).
then it is transported back to the adipose tissue, where LPL hydrolizes it to form IDL. this is then transported back to the liver. in the adipose tissue, the LPL is used to hydrolyze the FA from the TGs carried by this chylomicron n VLDL.
remember, LPL is activated by apoC.
it is in kaplan notes (biochem) but it was best explained in the kaplan videos (biochem).