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I am super excited, just got notified by amazon that my pre-ordered FA 2011 was shipped. While I am looking forward to using it and annotating it (I have been using the 2009 version so far), I am a bit worried that the complete list of errata won't be published until later this year (and I would hate to study wrong info!) So here's my suggestion: I will post any errors I notice in this thread. It would be great if other folks who are using FA 2011 would also do the same, that way we can help each other. Even if you aren't sure it's an error, we can discuss it and figure out the correct info. Happy studies!

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Correct me if I am wrong, but I believe that on pg. 464, under "Shift into cell (causing hypokalemia)", alkalosis would cause a decrease in the K+/H+ exchanger...:confused:

emedicine states: "pH: (1) Alkalosis enhances potassium entry into cells, and (2) acidosis impairs potassium entry into cells."

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i would go over it.. On my exam i got a antifungal medication lol

i got lucky i got it right... but dont believe the teachers when they say that theres a 5% possibility that those questions will appear... its always the things that you dont think will ever appear.. do lol..

I remember when i wrote my exam... I felt like they were testing everything i didn't know much about haha, got quite upset cause of it :p

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Correct me if I am wrong, but I believe that on pg. 464, under "Shift into cell (causing hypokalemia)", alkalosis would cause a decrease in the K+/H+ exchanger...:confused:

emedicine states: "pH: (1) Alkalosis enhances potassium entry into cells, and (2) acidosis impairs potassium entry into cells."
I think you're right that there's a mistake, but I think it's that under "Shift out of cell (causing hyperkalemia)", acidosis and severe exercise have the arrow going the wrong way, and it should indicate a decrease in the K+/H+ exchanger. The pump trades intracellular protons for extracellular potassium, right? So in acidosis, there would be plenty of H+ outside of the cell - exchange would slow down. In alkalosis, there would be relatively little H+ outside of the cell, so the exchange would be favored.

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pg 82 -

cloning methods- i think its out of order here. Your first isolate tissue mRNA-->reverse transcribe to cDNA (because bacteria don't have the same snRPS to to chaperone cleavage of introns...and mRNA already have introns spliced out)...then you insert into plasmid...then you grow and select...

Cre Lox system - antibiotic controlled promoter...a little misleading, just to clarify (make it easier)

Basically Cre recombinase gene is the one that we can induce with antibiotic promoter..this is in a random location of the plasmid (really doesnt matter) recombines DNA by cleaving at loxP sites (short but specific sequences artificially made) between loxP sites are usually "stop sequences" ....we place this in between promoter of gene of interest and downstream gene -->this is removed and degraded and then we can translate gene.

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pg 78- cholesterol

My understanding is that cholesterol has a dual effect on membrane fluidity depending on temp

increases fludity at lower temp/physiological temp - due to its impedance of phospholipids lining up to form an amorphous solid (this is similar to adding unsaturated FA's in tails of phospholipids.

decreases fluidity at higher temp - I am unsure as to the mechanism here, my presumption is that we have something bulky in there which is harder to move aroudn than smaller FA's chains of similar phospholipids.

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Fa 2011

For all the people studying to take the exam this year, If you have the chance to buy FA 2011 I will recommend it. It has more stuff. I have 2010 and 2011 and it really has a lot of little changes that at the end of the day are really important. Little details that make the difference.

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First Aid 2011 unofficial errata

Hi friends i am posting few errors in first aid .. please spend some time and correct these before you go for your exam....

page number :107
Catecholamine synthesis - "Carbidopa" should be written on the line above, indicating that it inhibits dopa decarboxylase.

page number :200
Lymph drainage - #5 should read "Rectum (lower part), anal canal above the pectinate line."

page number :244
Drug Reactions - #4, GI - Acute cholestatic hepatitis - cross through "macrolides" as a class effect, and add "erythromycin estolate."

page number :297
Neuroblastoma - Add that "Tumor marker is Bombesin" and "Histology reveals Homer-Wright rosettes."

page number :425
Dementia - Under Lewy body description, "hallucinations" should say more specifically, "visual hallucinations."

page number :446
Postpartum mood disturbances - Postpartum depression -Duration should be "2 weeks to > 1 year" rather than "2 weeks to 2 months."

page number :474
Ethacrynic acid -Ethacrynic acid can cause hyperuricemia and acute gout.

page number :488
Pregnancy complications-Ectopic pregnancy - Should say "positive hCG," not "?hCG," as hCG is actually often lower than expected based on gestational age with ectopic pregnancy.

page number :489
Most common causes of anovulation - Cross "Asherman's syndrome" off ofthe list. Asherman's syndrome can cause amenorrhea, but it does not cause anovulation.

page number :521
Rash on palms and soles - Add "Coxsackievirus A."

page number :523
Homer Wright rosettes - Remove "retinoblastoma" from list and add "Ewing's sarcoma." Retinoblastoma may have Flexner-Wintersteiner rosettes.

page number :525
Cowdry type A bodies - Cross through "yellow fever," and add "CMV." Yellow fever may result in councilman bodies.

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Helicobacter pylori - Newest triple therapy is proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole.

Herpesviruses - CMV - "owl's eye inclusions" are the Cowdry type A inclusions.

RNA viruses - Reovirus - Coltivirus is the viral genus responsible for Colorado tick fever. Genus Coltivirus is a member of the Reovirus family.

RNA viruses - Paramyxoviruses - In cases of infants with RSV, please know it is recommended NOT to use ribavirin.

Yellow fever - replace symptom of "black vomitus" with "hemorrhagic disease" which manifests in different manners including coffee-ground emesis (black vomitus), hematuria, epistaxis, and ecchymosis.

UTI bugs - Leukocyte esterase - positive indicates the presence of leukocytes and general inflammation which is present in bacterial infection but may also be present in other situations.

Antibiotics to avoid in pregnancy - Erythromycin should be removed from this list as it is a class B in pregnancy. More specifically, erythromycin estolate should be avoided only in patients with current liver disease (not pregnancy) because of its potential for worsening liver damage.

Oncogenic microbes - EBV also can cause Hodgkin's lymphoma and oral hairy leukoplakia

Paraneoplastic effects of tumors - Erythropoietin elevation resulting in polycythemia may also be seen in hepatocellular carcinoma and pheochromocytoma (in addition to the already-listed renal cell carcinoma and hemangioblastoma).

Muscarinic antagonists - remove "pirenzepine" from the section. This drug is not available in the US; therefore, it is not likely to be on the USMLE.

Bacterial endocarditis - (last sentence of section) Strep. bovis is found in 15% of colon cancer patients and can cause endocarditis (also see on FA p146).

Cardiac tamponade - cross through Kussmaul's pulse. Pulsus paradoxus seen in cardiac tamponade is different and distinct from Kussmaul's sign (JVD with inspiration) seen in constrictive pericarditis.

Cushing's syndrome - (right margin) The upward arrows may confuse the reader into thinking that dexamethasone will elevate cortisol levels in those scenarios. It would be more accurate to replace all of the upward arrows in the margin with "unchanged cortisol" or "no change in the abnormally elevated cortisol."

Digest tract anatomy – Muscularis mucosae is misspelled in the illustration as “Mucularis mucosae.”

Wilson's disease - remove "Choreiform movements" from the list of characteristic Wilson's features. Next to "Dementia," add Dyskinesia and Dysarthria.

Acute pancreatitis - Chronic calcifying pancreatitis section should refer the reader to Image #118.

Lab values in anemia - add 2 up arrows to the row for the serum Fe/TIBC ratio under the anemia of chronic disease column. One of the most common scenarios when the Fe/TIBC ratio is used is in determining whether a microcytic anemia is due to iron deficiency or anemia of chronic disease.

Aspirin - cross reference to additional section on Aspirin found on FA p391.

Pseudogout - can be treated with either colchicine or NSAIDs.

Primary brain tumors –medulloblastomas do not have "perivascular pseudorosettes" but do have "Homer-Wright rosettes."

Keeping "schizo-" straight - Schizoid + odd thinking does NOT equal schizotypal Schizoid and schizotypal are two distinct personality disorders discussed on FA p448.

Alcohol - Intoxication - Alcohol intoxication is not treated with naltrexone; however, naltrexone has been proven to be useful in relapse prevention.

Treatment for psych - Anorexia/bulimia - Cross-out anorexia because while bulimia responds well to SSRI therapy, anorexia nervosa does not.

ACE Inhibitors - In the toxicity section change "Proteinuria" to "Proteinuria prevention"

Sex chromosome disorders - Turner's syndrome incidence is "1:3000".

Malignant breast tumors - Additional risk factors for breast cancer include female gender, age, early first menarche, not becoming pregnant before age 30, late menopause, breast cancer in a first degree relative, BRCA gene mutation, and prior breast cancer.

Penile pathology - Erythroplasia of Queyrat is not "similar to Bowen's disease" but rather "a form of Bowen's disease"

Alveolar gas equation - PACO2/R and PACO2/0.8 should both be Pa, rather than PA

"Worst headache of my life" - To further clarify, the most common cause of spontaneous, nontraumatic SAH is a ruptured berry aneurysm.

The most common infratentorial brain tumor in kids is astrocytoma > medulloblastoma > ependymoma.

HLA-B27 - Add in Psoriatic Arthritis and Inflammatory Bowel Disease to the list. PAIR is the mnemonic to remember these.
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