Medullary segment of thick ascending limb - where the Na/K-2Cl pump is - which is where loop diuretics block. The Na/K-2Cl pump generates free water. The two type of water in urine: obligated and free. If the water is obligated, then the water is obligated to go out with every Na, K, and Cl (concentrated urea). Basically 20 ml's of obligated water for every Na, K, Cl (it's obligated) via Na/K/2Cl pump. The ADH hormone absorbs free water b/c the pump generates free water.
Let's say you absorb one Na, how much free water is left behind in the urine? - 20 mls; then reabsorbed another K, that is another 20, so its up to 40; another 2 Cl's are reabsorbed which is another 40; therefore, for absorbing one Na, one K, and 2 Cl's, you have taken 80 mls of free water from the urine - this is free water that is generated; its is this pump that loop diuretics block, which is in the thick ascending limb of the medullary segment.
this is what said told in goljan audio....but cant understand..if na-k-2 cl cotransport causes 80 ml of free water absorbed..but also said that ""
Let's say you absorb one Na, how much free water is left behind in the urine? - 20 mls; then reabsorbed another K, that is another 20, so its up to 40; another 2 Cl's are reabsorbed which is another 40; therefore, for absorbing one Na, one K, and 2 Cl's, you have taken 80 mls of free water from the urine - this is free water that is generated; its is this pump that loop diuretics block, which is in the thick ascending limb of the medullary segment.
this is what said told in goljan audio....but cant understand..if na-k-2 cl cotransport causes 80 ml of free water absorbed..but also said that ""
If the water is obligated, then the water is obligated to go out with every Na, K, and Cl (concentrated urea). Basically 20 ml's of obligated water for every Na, K, Cl (it's obligated) via Na/K/2Cl pump""
so whats true--na/k/2 cl cotranport associated with free water or obligated water..
so whats true--na/k/2 cl cotranport associated with free water or obligated water..