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Discussion Starter · #1 ·
So I'm well aware of sulfonamide drugs being able to cause hemolysis in G6PD Deficiency, but I can't seem to understand how.

I know they antagonize the synthesis of folate but I don't understand what that has to do with HMS?
 

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Discussion Starter · #4 ·
Sulfa drugs produce free radicals and G6PD deficient individuals are unable to detoxify them causing RBC damage
The first part of your response, I am well aware. But HOW do sulfa drugs place stress on the hexomonophosphate shunt? How do they produce free radicals? The biochem does not go into that. In fact most websites just say it puts "stress" on the system and causes hemolysis.

I did just find a source that lists sulfonamides as "alanine radicals"...but the mechanism of action is still unknown. It seems like we know sulfa drugs can precipitate RBC destruction from empirical evidence but nothing from a theoretical perspective.
 
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