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Two patients with hemophilia A have been found to have disease due to de novo insertion of L1 LINE into exon 14 of factor VIII gene during embryogenesis or maternal oogenesis although L1 LINES are common within human genome almost all those carried by humans today are unable to move. which of the following is a characteristic of a very rare insertion that created hemophilia in these two patients?


A) DNA polymerase delta activity was required to insert LINE sequence in the new site
B) homologous DNA recombination was required to insert LINE sequence in the new site
C) RNA polymerase II activity was required to insert to insert LINE sequence in the new site
D) RNA polymerase III activity was required to insert to insert LINE sequence in the new site
E) transposase activity excised the LINE from its previous location and inserted into the Exon
 
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E really?

E are u sure? i hadnt read anything to do with eukaryotic genes and transposase. does the same apply?
doctor F where are u getting these questions? they seem so.. arrgggghhh!!:confused:
 

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Two patients with hemophilia A have been found to have disease due to de novo insertion of L1 LINE into exon 14 of factor VIII gene during embryogenesis or maternal oogenesis although L1 LINES are common within human genome almost all those carried by humans today are unable to move. which of the following is a characteristic of a very rare insertion that created hemophilia in these two patients?

A) DNA polymerase delta activity was required to insert LINE sequence in the new site
B) homologous DNA recombination was required to insert LINE sequence in the new site
C) RNA polymerase II activity was required to insert to insert LINE sequence in the new site
D) RNA polymerase III activity was required to insert to insert LINE sequence in the new site
E) transposase activity excised the LINE from its previous location and inserted into the Exon
C) RNA polymerase II activity was required to insert to insert LINE sequence in the new site
I think C is more probable then E.
As LINE (long interspreaded nuclear elements) uses copy- paste mechanism to insert there sequence in genome. (So inmovable)
Whereas
Transposons use cut-paste method.

I know its outdated question but looking for insight guys.
 
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