Hemosiderin-laden Macrophages
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After hemorrhage, RBCs leave to the ECF releasing their hemoglobin
Then comes the macrophage phagocytosing them and transforming hemoglobin Iron to hemosiderin giving a brown pigment.
The causes that I can come up with now:
of course any Iron overload situation [hemachromatosis]
but also
Brown tumors seen in bones in hyperparathyroidism
and
Heart failure cells seen in pulmonary edema
Don't forget that you need "Prussian Blue" stain to see these hemosiderin-laden macrophages.
Then comes the macrophage phagocytosing them and transforming hemoglobin Iron to hemosiderin giving a brown pigment.
The causes that I can come up with now:
of course any Iron overload situation [hemachromatosis]
but also
Brown tumors seen in bones in hyperparathyroidism
and
Heart failure cells seen in pulmonary edema
Don't forget that you need "Prussian Blue" stain to see these hemosiderin-laden macrophages.
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