USMLE Forums banner

hyperpigmentation on posterior aspect of the neck

2610 Views 3 Replies 3 Participants Last post by  ecgram
A 52-year-old obese female with a history of diabetes mellitus type II presents to your office, complaining of a brown hyperpigmentation on the posterior aspect of her neck. A biopsy of the area shows epidermal thickening. Which of the following malignancies is she not at risk for?
A. Breast
B. Stomach
C. Colon
D. Uterus
E. Lung
1 - 2 of 4 Posts

the question is basically a 2 step question..first it want's u to identify what the patient is having??

it is- Acanthosis Nigricans-defined as an asymptomatic area of skin darkening and thickening..(may be associated with pruritus)
Next- u should know common malignancies associated with it-
out of the options given,breast,stomach,lung,uterus are known to be associated with this.
so answer is COLON.(ref-F.A.2010,pg 222)

u should also know why this is being seen in this patient,
because acanthosis nigricans is seen in Insulin resistance states...
hyperpigmentation questn contd

another very imp fact to know is in which else endocrine conditions acanthosis nigricans seen-

1-Diabetes Mellitus
2-Cushing's disease
3-polycystic ovarian disease
1 - 2 of 4 Posts
This is an older thread, you may not receive a response, and could be reviving an old thread. Please consider creating a new thread.