I always found this little chart helpful, hope this helps you also, and i'm already taking into account that you sort of know what they are already...
CharacteristicsPemphigus vulgarisBullous pemphigoid
Age= Middle age, Elderly Clinical Features =MonomorphicPolymorphic Blisters= Rupture easily, Flaccid Tense, firm Content of Blisters= fluid filledoften hemorrhagic Oral Lesions=Common Rare Nikolsky's sign= Positive Negative Tzanck smear= Acantholysis No Acantholysis D. Immunoflourescence= Intraepidermal deposits Deposits at the epidermal basement membrane zone= Target antigenDesmoglein 1 & 3 BPAG2- -(type 17 collagen)
I always remember it like this to get me started. Like on the test, I'm not going to sway, its going to be clear cut / black and white
pemphigus vulgaris- is vulgar, meaning swears a lot/mouthy. Blisters in the mouth and mucus. Because the blisters go in more places its going to have a more serious effect. then add AB against desmosomes, circular immunoflurescence, in epidermis, oral lesions.
Key to know: AB against Desmosomes, oral lesions in mouth
Bullous pemphigoid- is only on the skin. Ab against hemidesmosomes, linear immunofluoresence, subepidermal, floating keratinocytes
Key to know: AB against hemidesmosomes, no blisters in oral/mucosa
They will ask you a clinical question, something like;
a 4 year old girl started to have blisters on her skin that slough off easy, when you exam her you noticed blisters in the mouth. You run some tests and see there are some circular immunoflurence, what else would you see?
A) AB against desmosomes
B) floating keratinocytes
C) Ab against hemidesmosomes
D) Double Stranded DNA virus