USMLE Forums banner

1 - 2 of 2 Posts

·
Registered
Joined
·
6 Posts
Discussion Starter #1
As I understand, insulin is the main anabolic hormone.
Growth Hormone obviously also promotes growth, through IGF-1.

However, isn't IGF-1 counterregulatory to insulin and decreases insulin secretion? I don't see how a decrease in insulin would be conducive to growth.
 

·
Registered
Joined
·
3 Posts
growth hormon has anabolic( direct and indirekt) and catabolic effect. indirekt effects of gh via ıgf-1.
Direct anabolic effect of gh -> a.a. uptake into the cell and increase protein synthesis
İndirect anabolic effect of gh -> (via ıgf -1) stimulate ephiyphsial plate thereby occur increase in bone lenght
Catabolic effect of gh -> increase glucose and fatty acids(lipolisis) in blood as stress hormone
consequently ı think igf-1 isn't countregulatory of insulin because its not related with glucose. but gh it is.
 
1 - 2 of 2 Posts
Top