[lemontea88]

Woman, difficulty breathing for 1.5 hours. Wheezing is heard. Lab tests show an increased eosinophil count and eosinophils in the sputum. Which of the following is the most likely sequence of events for initial sensitization to the allergen causing these findings?

A) Cytokine release, then IgE production, then T lymphocyte induction
B) IgE production, then B lymphocyte activation, then T lymphocyte induction
C) IgE production, then T lymphocyte induction, then cytokine release
D) T lymphocyte induction, then cytokine release, then IgE production

What do you guys think is the answer, and why?

I do not know what is the answer.

 

[DrSeddik]

Th2 activation----> release of IL4,5,6, CD40L -----> B cell class switching into IgE production by alternative mRNA splicing. ----> IgE synthesis. The trick is all of this happened a long time before the presentation.

 

[lemontea88]

Dr. Seddik, you wrote your Step 1 already? Loong time didnt see you here.

 

[DrSeddik]

Dr. Seddik, you wrote your Step 1 already? Loong time didnt see you here.

I will take it Soon

 

[lemontea88]

I will take it Soon

Ahh I see. All the best! Can't wait for you to be free so that you can start posting interesting and tricky questions like how you used to last time.

 

[wasify81]

d this q in nbme 6.