A 3-year-old boy with mental retardation has hepatosplenomegaly. Analysis of tissue obtained on biopsy of the liver shows unusually large amounts of glucocerebroside. Which of the following enzymes is most likely to be deficient?
(A) Hormone-sensitive lipase
(B) Lipoprotein lipase
(C) Lysosomal hydrolase
(D) Sphingolipid synthase
(E) Tissue phospholipase
(A) Hormone-sensitive lipase
(B) Lipoprotein lipase
(C) Lysosomal hydrolase
(D) Sphingolipid synthase
(E) Tissue phospholipase