I have just been reading about volatile anaesthetics.
It's said that blood/gas coefficient represents solubility in blood and when it's high it delays the onset of action. While the blood/lipid coefficient corresponds with solubility in tissues, it's directly proportional to arteriovenous concentration gradient and it is also proportional to time needed for onset of action.
From what I have already known, blood/lipid coefficient is directly proportional to potency (inversly proportional with MAC), it does not affect neither the time of onset of action, nor the arteriovenous concentration gradient (blood/gas partition coeffecient does).
Does anyone have a background about this? it was confusing when I first went over it, now my head is spinning and I am definitely seeing birds..
It's said that blood/gas coefficient represents solubility in blood and when it's high it delays the onset of action. While the blood/lipid coefficient corresponds with solubility in tissues, it's directly proportional to arteriovenous concentration gradient and it is also proportional to time needed for onset of action.
From what I have already known, blood/lipid coefficient is directly proportional to potency (inversly proportional with MAC), it does not affect neither the time of onset of action, nor the arteriovenous concentration gradient (blood/gas partition coeffecient does).
Does anyone have a background about this? it was confusing when I first went over it, now my head is spinning and I am definitely seeing birds..