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Ito cells are the osteoblasts or fibroblasts of the liver. They have the following functions:
uptake and storage of vit A
synthesis of extracellular matrix
synthesis and release of metalloproteinase and collagenase inhibitors
cytokine synthesis and release

These cells play an important role in cirrhosis. They are activated by cytokines from Kupffer cells and hepatocytes to transform into myofibroblast phenotype and synthesise collagen
 
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