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Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß2 subunit of LFA1 family (ß2 integrins). These are known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium).

Leukocyte adhesion deficiency type II (LAD II) is extremely rare. It is a defect in selectins types E and P expressed on endothelial cells, and also sialyl Lewis-X expressed on leukocytes.
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