Below is the list of important drugs that have active metabolites;
1) Acetohexamide (can cause renal dysfunction)
2) Atracurium = Laudanosine(can cause seizures)
3) Acetaminophen = N-acetyl benzoquinonamine (hepatic necrosis & failure)
4) Ethanol = Acetaldehyde (folate inactivation & thimine ,disulfiram like reaction)
5) Morphine = Morphine 6 glucoronide(renal toxic)
6) Meperidine = Nor meperidine(Serotonin synd)
7) Glyburide (renal dysfunction)
8) Imepinem (nephrotoxic metabolite)
9) Sulfonamide (crystalluria)
(you are welcome to add more to the list
)
1) Acetohexamide (can cause renal dysfunction)
2) Atracurium = Laudanosine(can cause seizures)
3) Acetaminophen = N-acetyl benzoquinonamine (hepatic necrosis & failure)
4) Ethanol = Acetaldehyde (folate inactivation & thimine ,disulfiram like reaction)
5) Morphine = Morphine 6 glucoronide(renal toxic)
6) Meperidine = Nor meperidine(Serotonin synd)
7) Glyburide (renal dysfunction)
8) Imepinem (nephrotoxic metabolite)
9) Sulfonamide (crystalluria)
(you are welcome to add more to the list