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Discussion Starter · #1 ·
A 78-year-old man is seen in the doctor’s office for a nonproductive cough, 9-kg (20-lb) unintentional weight loss, and bilateral breast enlargement, all occurring within the past 6 months. He has smoked two packs per day for the past 40 years. His past medical history is otherwise unremarkable, and he takes no medications. His temperature is 36.7°C (98.1°F), blood pressure is 125/85 mm Hg, pulse is 68/min and regular, respiratory rate is 15/min, and oxygen saturation is 99% on room air. There are crackles at the left lower lung field and a ridge of symmetric glandular tissue (1 cm in diameter) around the nipple-areolar complexes of both breasts. Complete blood cell count shows a WBC count of 6000/mm3; hemoglobin of 14.7 g/dL, and platelet count of 210,000/mm3. All other laboratory results are
normal. X-ray of the chest shows a focal 5-cm mass lesion in the left lower lung corroborated by CT scan. Which of the following is most likely histologic type of lung cancer present in this patient?
(A) Adenocarcinoma
(B) Bronchoalveolar cell carcinoma
(C) Large cell carcinoma
(D) Small cell carcinoma
(E) Squamous cell carcinoma

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The paraneoplastic syndromes can be tricky to remember, but I always think:
large cell carcinoma = large boobs......:rolleyes:
Yes indeed big boobs/large cell (Thanks healer 2B)

Some more examples of paraneoplastic syndrome!

  • SCCs are more likely to be associated with hypercalcemia due to parathyroid-like hormone production.
  • Clubbing and hypertrophic pulmonary osteoarthropathy and Trousseau syndrome of hypercoagulability are caused more frequently by adenocarcinomas.
  • The syndrome of inappropriate antidiuretic hormone production (SIADH) is more common in SCLC but can also occur in NSCLC.
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