[indian]

12 year old with lymphadenopathy hepatomegaly lymphocytosis autoimmune features and persistent lymphocytes activation after exposing his blood sample to T cell mitogen.

What is your diagnosis?

 

[indian]

Ok it seems that nobody can answer your question

Why don't you tell us the correct answer?

 

[indian]

Canale Smith Syndrome

 

[Betro Sadek]

Canale Smith Syndrome

i thought in this syndrome .. but there is no lymphocytosis in it .. as i remember ...

it ofcource it goes with FAS mutation

 

[indian]

i thought in this syndrome .. but there is no lymphocytosis in it .. as i remember ...

it ofcource it goes with FAS mutation

They don't give you everything in USMLE, the fact there's lymphoid organs enlargement is enough to point to an activated immune system.

Yes, of course it's Fas and FasL mutation so that they don't work so that activated T lymphocytes don't kill each other after finishing their job.

 

[karthiksamineni]

Canale Smith Syndrome

can some explain clearly about Canale Smith Syndrome? plz

 

[lee-usmle]

can some explain clearly about Canale Smith Syndrome? plz

All you need to know for the USMLE is this;
Canale smith syndrome = activated lymphocytes due to FAS gene mutation, this activation leads to lymphadenopathy and autoimmunity.