[khanar]

Any mnemonics for them?
It's killing me
I just can't memorize them

 

[khanar]

OK relax,
I'll walk you through them and by the end of my post you should feel better

First of all when there's two confusing points "focus on one of them and in the exam you'll remember the other by being not what the first is" have to say that I learned this tip from Goljan

Now let's get started

--All AR except Fabry and Hunter XR : so the Hunter is pointing his gun to the X target. Hurler who's like Hunter [is Mucopolysaccharidosis] but because of corneal clouding he can't hunt well. By the way both Hunter and Hurler accumulate Heparan sulfate [dermatan sulfate is easy to remember once you get the first]. All you need to really memorize then is Hurler is alfa iduronidase and you'll remember the other by exclusion.

--No man picks is nose with hi- Sphinger "Nieman Pick - Sphingomyelinase".

--Gaucher-Glucocerebrosidase-Glucocerebroside 3G "have u Got ur iPhone 3G!"

--Cherry-Red spot is a hyphenated term and so as Nieman-Pick and Tay-Sach.

--Ashkenazi Jews have Tay-Sachs Nieman-Pick and Gaucher common.

--Angiokeratoma is a Fabric of vessels and Galaxy of skin spots: which means that Angiokeratoma is seen in Fabry disease in which there's Galactosidase deficiency and epidermal keratosis.

--Krabbe's disease: just remeber Globoid Cells

--Metachromatic Leukodystrophy: ... well I don't know how to remember Aryl sulfatase

 

[khanar]

Metachromatic Leukodystrophy

Metachormatic Leukodystrophy

Just remember that the name came from metachromasia (Yellow brown color shift of the sulfatides crystals with toluidine blue).
Arysulfatase A deficiency

 

[pkul85]

My mneumonic is kinda adjusted :

Now here is how i think of it :

Neiman Picks his nose with his "SPHING"er ( finger...so defeciency of sphingomylinase) Because he picks his Nose, he eats his boggers ( nose crap) and gets fatter ( Hepatosplenomegaly- fat stomach)

Using this mneumonic + the other one someone mentioned above ( hyphenated words= Cherry-red macula spot) + the order listed in FA.

FA order:-1- Gauchers 2- Neiman -Pick 3- Tay-sachs

1 and 2- have hepatosplenomegaly in common

2 and 3- Are both hyphenated , i.e- Cherry-Red macula, in common. ( from other poster's mneumonic)

So, if u see patient has BOTH HEPATOSPLENOMEGALY AND CHERRY-RED MACULA, it has to be the one in the middle- Neiman-Pick.
(Neiman likes picking things-- just like he likes picking his nose- so, he picks BOTH!! --CHERRY red macula AND HSmegaly!)

------------------------------------------------------------------

TAY-SACHS:

This mnemonic was told to us in kaplan by one of the profs ( i dont remmber name at the moment).. But since then i have forgotten the original wording- but can somehow keep the story strung together. So, bear with me. If this helps u, that's good.. if not im soo sorry for confusion!

There was a boy named TAY who couldnt see well because of cherry red spots on his macula. One night, despite having bad vision, this RETARDED kid took his GM2 out at night and crashed into a witch. Before dying the witch placed a HEX on him.

I think of this story and analyze it this way=

"boy- i think small boy- he can not be fat-- so no hepatosplenomagaly
"named TAY" - Tay sachs disease
"cant see well" b/c of the cherry red macula spot"
"drove at night time"-- also helps me think -- vision, cherry red spot
"took his GM2 car"- GM- stands for general motors : In our case its "gm2"ganglioside
"retarded"- this one is a bit confusing bc this is not mental retardation- but think progressive neurodegeneration and developmental delay-- so BRAIN ISSUES
"placed a HEX on him" A hex in normal language is a curse.. However to us, this means "hexosaminidase A" defeciency.

If this helps even one person, ill feel better

 

[pkul85]

Men are evil hunters who always fabricate lies.

Men- XR
Hunters disease
Fabry's Disease

 

[monsalg2502]

Thanks for your mnemonic it is really helpful....
I add a personal touch ...hope it helps !

There was a boy named TAY who couldnt see well because of cherry red spots on his macula. One night, despite having bad vision, this RETARDED kid took his GM2 out at night and crashed into a witch. Before dying the witch placed a HEX on him.

About the HEX the witch placed on Tay...

His skin would turn into ONIONS every time he told a lie...

Lysosomes with onion skins

 

[missgrace]

My mneumonic is kinda adjusted :

Now here is how i think of it :

Neiman Picks his nose with his "SPHING"er ( finger...so defeciency of sphingomylinase) Because he picks his Nose, he eats his boggers ( nose crap) and gets fatter ( Hepatosplenomegaly- fat stomach)

Using this mneumonic + the other one someone mentioned above ( hyphenated words= Cherry-red macula spot) + the order listed in FA.

FA order:-1- Gauchers 2- Neiman -Pick 3- Tay-sachs

1 and 2- have hepatosplenomegaly in common

2 and 3- Are both hyphenated , i.e- Cherry-Red macula, in common. ( from other poster's mneumonic)

So, if u see patient has BOTH HEPATOSPLENOMEGALY AND CHERRY-RED MACULA, it has to be the one in the middle- Neiman-Pick.
(Neiman likes picking things-- just like he likes picking his nose- so, he picks BOTH!! --CHERRY red macula AND HSmegaly!)

------------------------------------------------------------------

TAY-SACHS:

This mnemonic was told to us in kaplan by one of the profs ( i dont remmber name at the moment).. But since then i have forgotten the original wording- but can somehow keep the story strung together. So, bear with me. If this helps u, that's good.. if not im soo sorry for confusion!

There was a boy named TAY who couldnt see well because of cherry red spots on his macula. One night, despite having bad vision, this RETARDED kid took his GM2 out at night and crashed into a witch. Before dying the witch placed a HEX on him.

I think of this story and analyze it this way=

"boy- i think small boy- he can not be fat-- so no hepatosplenomagaly
"named TAY" - Tay sachs disease
"cant see well" b/c of the cherry red macula spot"
"drove at night time"-- also helps me think -- vision, cherry red spot
"took his GM2 car"- GM- stands for general motors : In our case its "gm2"ganglioside
"retarded"- this one is a bit confusing bc this is not mental retardation- but think progressive neurodegeneration and developmental delay-- so BRAIN ISSUES
"placed a HEX on him" A hex in normal language is a curse.. However to us, this means "hexosaminidase A" defeciency.

If this helps even one person, ill feel better

This helps me!

Also - think carrying a Sack of Onions.

For Gaucher - I think of Ocscar the Grouch - (Gauch) in the trash with crumpled up paper (cytoplasm)

And from a friend - better Foam in after you Pick you nose (Neiman Pick foam cells).

That's all I got...

 

[szaldivarr]

Any mnemonics for them?
It's killing me
I just can't memorize them

Hey !! If you have twitter I suggest you follow @master_usmle he has lots of great Mnemonics for Step 1. It's very helpful

 

[fizA]

Tay Sachs

Tea Snacks were Delayed, so GM ate Cherries and Onions with mr.hexosaminidase .

tea snacks= tay sachs
delayed= devp delay
GM(general manager)= GM2 ganglioside
cherries= chery red spots
onions=lysosomes with onion skin
hexosaminidase

 

[erikkka]

meneumonic for Gaucher's

I just came up with an easy way to remember Gaucher's.

"A fat (hepatosplenomegaly) Gaucho tried to ride his horse but fell and broke his femur (necrosis of femur, bone crises), it was bleeding so he put some crumbled tissue paper on it (Gaucher cells that resemble tissue paper).

btw, a Gaucho is sort of like a latin version of a cowboy. Not sure how to implement glucocerebrosidase in there. Hope this helps.

 

[DR SPRAKER]

naked vs capsuled virus.

Thanks so much.. can we start a thread about naked vs capsuled virus please?

OK relax,
I'll walk you through them and by the end of my post you should feel better

First of all when there's two confusing points "focus on one of them and in the exam you'll remember the other by being not what the first is" have to say that I learned this tip from Goljan

Now let's get started

--All AR except Fabry and Hunter XR : so the Hunter is pointing his gun to the X target. Hurler who's like Hunter [is Mucopolysaccharidosis] but because of corneal clouding he can't hunt well. By the way both Hunter and Hurler accumulate Heparan sulfate [dermatan sulfate is easy to remember once you get the first]. All you need to really memorize then is Hurler is alfa iduronidase and you'll remember the other by exclusion.

--No man picks is nose with hi- Sphinger "Nieman Pick - Sphingomyelinase".

--Gaucher-Glucocerebrosidase-Glucocerebroside 3G "have u Got ur iPhone 3G!"

--Cherry-Red spot is a hyphenated term and so as Nieman-Pick and Tay-Sach.

--Ashkenazi Jews have Tay-Sachs Nieman-Pick and Gaucher common.

--Angiokeratoma is a Fabric of vessels and Galaxy of skin spots: which means that Angiokeratoma is seen in Fabry disease in which there's Galactosidase deficiency and epidermal keratosis.

--Krabbe's disease: just remeber Globoid Cells

--Metachromatic Leukodystrophy: ... well I don't know how to remember Aryl sulfatase

 

[Linc]

Gaucher

A gaucho (argentinian cowboy) that is made of crumbled paper and a glucose brain. Because he is made of paper he falls a lot and has problems with his bones and spleen.

crumbled tissue paper macrophages
glucose brain -- glucocerebroside
bone fractures
hepatosplenomegaly

)

 

[ddeneve]

lysosomal storage mnemonics

A couple I made or modified:

Metachromatic leukodystrophy
"look at this trophy" → leukodystrophy
"April fools day" → arylsulfatase
"see bro, so fake" → cerebroside sulfate

Gaucher disease
Janice from Friends (Chandler's Jewish ex-girlfriend) with crumpled tissues in her hand saying
"Om my gosh, sweet bro"
gosh→ Gaucher
sweet bro→ glucocerebrosidase/glucocerebroside

Krabbe disease:
"Grabby milky boobs bro"
Grabby→ Krabbe
milky bro→ galactocerebrosidase/galactocerebroside
boobs→ globoid cells