[schiwei]

What is the difference between inhibiting dopamine receptors in the mesolimbic as opposed to the nigrostriatal pathways?

 

[gunner0101]

relieving psychotic symptoms vs inducing parkinsonian symptoms

note: when you block the mesolimbic pathway via typical antipsychotics (d2 receptor antagonists) you can cause a reflex increase in dopamine receptors on the nigrostriatal pathway...giving you tardive dyskinesia