An otherwise healthy 80 year old male is scheduled for a endoscopy for rectal bleeding. A standard dose of Midazolam is given intravenously. A few minutes later the patient developed cyanosis and labored inspirations and requires ventilation with a oxygenated resuscitation bag. An age related increase in which of the following is most likely the cause of the symptoms?
a. entero hepatic recycling
b. metabolite formation
c. plasma binding protein
d. sensitivity to sedative
e. volume of distribution
a. entero hepatic recycling
b. metabolite formation
c. plasma binding protein
d. sensitivity to sedative
e. volume of distribution