cytotoxic t lymhocytes.
Missing Beta 2 Microglobulin
Transgenic mice are generated which are incapable of expressing beta 2 microglobulin. Which of the following components of host defense is most likely to be altered in these mice?
A- Complement
B- Cytotoxic T lymphocytes
C- Interleukin 2 (IL2) secretion
D- Natural killer cells
E- Neutrophils
A- Complement
B- Cytotoxic T lymphocytes
C- Interleukin 2 (IL2) secretion
D- Natural killer cells
E- Neutrophils
1 - 14 of 14 Posts
I agree with youcytotoxic t lymhocytes.
isnt it LAD type 2??
and the answer is E??
and the answer is E??
Hey dr. muhamad I think beta2 microglobulin is part of the MHC 1 complex, which interacts with Cytotoxic t lymphocytes. So without this they probably cant be activated.isnt it LAD type 2??
and the answer is E??
P.S in LAD 2 it is an integrin defect, not microglobulin.:happy:
oh thanksP.S in LAD 2 it is an integrin defect, not microglobulin.:happy:
i thought they r both microglobulin
I dont think so. I have read that LAD 1 is an integrin defect and LAD 2 a selectin defect, but extremely rare.oh thanks
i thought they r both microglobulin
B- Cytotoxic T lymphocytes
B...
beta2microglobulin is the part of the MHC1 that is not encoded in the HLA-gene-complex. the MHC1 is used as an 'ID' for cells, so they are left unharmed by the cytotoxic CD8.
hope I'm right
beta2microglobulin is the part of the MHC1 that is not encoded in the HLA-gene-complex. the MHC1 is used as an 'ID' for cells, so they are left unharmed by the cytotoxic CD8.
hope I'm right
answer is B.cytotoxic T-cells.!
becoz MCH-1 is cytotoxic expressd on all the nucleatd cells in the body , beta2 micro transports antigen to cell surface through exogenous pathway and its not encoded in MCH1. so its mutation affects cytotoxic T cells.
becoz MCH-1 is cytotoxic expressd on all the nucleatd cells in the body , beta2 micro transports antigen to cell surface through exogenous pathway and its not encoded in MCH1. so its mutation affects cytotoxic T cells.
Same here...
I think is B. I do not add anything more to the explanation, as the most important concepts have already been said.
I think is B. I do not add anything more to the explanation, as the most important concepts have already been said.
1 - 14 of 14 Posts
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