[good_boy_1234]

A 2-year-old boy is brought to the physician because of mental retardation. Physical examination shows hirsutism and micrognathia. A review of the patient's records shows cardiac and renal abnormalities. Karyotypes are performed for both parents and the child, and the results are shown.


click to enlarge

Which of the following events is most likely responsible for the findings in this patient?
A. Adjacent I segregation
B. Adjacent II segregation
C. Alternate segregation
D. A recombination event within a paracentric inversion
E. A recombination event within a pericentric inversion

Source: Kaplan Q bank

 

[lynk]

i think its "recombination event within a paracentric inversion" as FA states that an unbalanced translocation occurs when "..the long arms of 2 acrocentric ch fuse at the centromere and the 2 short arms are lost."

pls correct me if i am wrong

 

[good_boy_1234]

i think its "recombination event within a paracentric inversion" as FA states that an unbalanced translocation occurs when "..the long arms of 2 acrocentric ch fuse at the centromere and the 2 short arms are lost."

pls correct me if i am wrong

Hi brother. It is E; Recombination event within a Pericentric inversion

 

[earthpole]

i think it is E

 

[struggle]

pericentric inversions include the centromere but here i dont think centromere is involved..
Can u plz explain it earthpole?

 

[struggle]

http://ghr.nlm.nih.gov/handbook/illustrations/inversion.jpg