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Discussion Starter #1
which of the following regarding the proteins muscarinic and nicotinic are tre?

a. muscarinic receptors have been found to carry signals via closely associated M proteins

b. nicotinic receptors activate the IP3 pathway leading to the release of stored Ca2+

c. drugs that act on nicotinic sites are important in blocking the undesirable side effect of salivation during the administration of inhaled anesthetics.

d. drugs that act on nicotinic sites are important for temporarily paralyzing patients before tracheal intubation

e. muscarinic receptors bind the endogenous ligand NE with high affinity
 

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Well okay -

Not a - well it could be a but I'm not sure what an M protein is beyond the fact that they are part of Streptococcus Pyogenes...

Not b - Nicotinic receptor mechanisms involve the Na+/K+ pump not second messengers - the mechanism describes is a Gq which is used at M1 and M3 receptors.

Not c because Nm and Nn are not at salivary glands - Nn are at the adrenal medulla nd the autonomic ganglia and Nm is at skeletal mucles

Not e because muscarinic receptors bind AcetylCholine, not NE

So by elimination D... I'm really not sure though... anyone else weigh in?
 
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