NBME question ,,, help

934 Views 3 Replies 3 Participants Last post by YSMU_grad_2013, Jan 31, 2015

dr mumble

Discussion Starter · Jan 16, 2015 (Edited)

hey everyone .. here is a question , seems very easy but the answer in offline key is wired everywhere .. kindly help

50year old with fever and shaking chills for 24 hoours, 1 week before tread by
a 5-FU for a tumor, on labs , counts WBC=400/mm3 platelet=1oo,ooo/mm3 and haemocrit 30 ..
which of the following should be best combined with drug

1) erythropoitin
2 GM-CSF
3) IL-1
4)IL_1
5) leucoverin

please help on this

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dr mumble

Discussion Starter · #3 · Jan 16, 2015

doctor_ind said:
what's the difference between IL-1 and IL_1??

I guess it it is GM-CSF

Fever and chills, so most probably neutropenia..

they are same
ok i got it later , infact i was confusing its mechanism with MTX that is DHF inhibitor (MTX will dec activation of the folic acid thats way we give leucoverin, already activated for of folic acid )but 5-FU is a thyamidylate synthase inhibitor dont reduce the activated form ,so answer is GM CSF , you are right ,

thanks

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