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A 43-year-old male presents to his primary care doctor with complaints of increasing abdominal girth. He has a long history of alcohol abuse and recently stopped drinking. Spironolactone is prescribed to aid in control of the patient’s increasing ascites. Which of the following is the site of action of spironolactone?

A) Ascending loop of Henle
B) Collecting duct
C) Descending loop of Henle
D) Distal tubule
E) Proximal tubule
 

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i think its collecting duct but i did this question before somewhere and it says distal tubule
cant think where i did it
 

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I think its late distal tubule and collecting duct, but since we have to choose one we choose collecting duct.

The most recent Kaplan Pharm book shows aldosterone receptors in the collecting duct under this topic but if you look at the wiki entry for aldosterone it says they're present in principal cells in both the collecting and the distal convoluted tubule... Since spironolactone is an aldosterone antagonist it follows that it should work where the aldosterone receptors are so that may be the source of the confusion.

I think generally though, if you see this, you go with collecting duct.
 
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