[hana]

OK I know that estrogen increases HDL and decreases LDL but progestrone acts the reverse.

1- What would be the net result when we are taking combination estrogen-progesterone OCP?
2- How OCP increases risk of cardiovascular disease?
3- HOW OPC increases risk of DVT? (IS IT THE ANTITROMBINE impairment b/c of estrogen part?)

 

[hana]

Is the question not worth of discussion or just others like me do not have the answer? :notsure:

 

[Mondoshawan]

3- HOW does OCP increase risk of DVT? (IS IT THE ANTITHROMBIN impairment b/c of estrogen part?)

That was the main theory before, but it seems like it's more complicated now:

A recent randomized, crossover study confirmed that there are increases in the levels of prothrombin, factor VII, factor VIII, factor X, fibrinogen, and prothrombin fragment 1+2 and decreases in the levels of factor V during the use of oral contraceptives. The increase in prothrombin and factor VII and the decrease in factor V were significantly more pronounced with the use of third-generation oral contraceptives (those containing desogestrel) than with the use of second-generation oral contraceptives containing levonorgestrel. It is now recognized that moderately increased levels of prothrombin and factor VIII are associated with an increased risk of venous thrombosis. Since factor V may exhibit anticoagulant activity because of its ability to act as a cofactor in the inactivation of activated factor VIII that is mediated by activated protein C, a decrease in the level of factor V may contribute to the thrombotic side effects of oral contraceptives.

 

[Mondoshawan]

Is the question not worth of discussion or just others like me do not have the answer? :notsure:

I don't know about 1 or 2... I guess obviously there would be the increased risk of thrombotic coronary events because of increased arteriothrombosis with OCP, especially in a smoker. Also, don't some synthetic progestins increase CRP levels (I have no source for this, but it rings a bell)?

:notsure: