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Remember that p450 is cytochrome p450 - it uses a heme molecule in the active site for electron transfer. More demand for cytochrome = more demand for heme; in someone with porphyria, that means more buildup of substrates from behind the messed-up link in the pathway...

hope that helps! :)
 

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Discussion Starter · #3 ·
Remember that p450 is cytochrome p450 - it uses a heme molecule in the active site for electron transfer. More demand for cytochrome = more demand for heme; in someone with porphyria, that means more buildup of substrates from behind the messed-up link in the pathway...

hope that helps! :)
Oh man I can't believed I missed the obvious, lol thank you!
 
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