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Discussion Starter · #1 ·
Let's give it a quick shot;

By definition these are remote cancer effects not caused by metastasis

Lung small cell --- ACTH --- Cushing
Lung small cell --- ADH ---- SIADH
Lung squamous --- PTH related peptide --- Hypercalcemia
Renal cell ----- PTH ---- Hypercalcemia
Thymoma and Lung small cell ---- AB against presynaptic NMJ Ca receptors --- Myasthenia (Lambert-Eaton syndrome)
Intracranial Neoplasms ---- ADH ---- SIADH
Leukemia/Lymphoma ---- Gout
Pancreas ----- Migratory thrombophlebitis (Trousseau syndrome)
Carcinoid tumor --- 5HIAA --- Carcinoid syndrome
Any lung cancer --- Hypertrophic pulmonary osteoarthopathy
Stomach and other visceral malignancies --- Acanthosis nigricans

Do you have more to add to the list!
 

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Acanthosis Nigricans

I don't think Acanthosis Nigricans is a paraneoplastic syndrome
It might be associated yes but it's not due to tumor chemical or hormone secretion of any kind
 

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It's not 5-HIAA that is secreted by carcinoid tumors and causes carcinoid syndrome. Carcinoids secrete 5-HT (along with other products such as histamine, dopamine, substance P, neurotensin, prostaglandins, kallikrein, and tachykinins). 5-HIAA is a urinary metabolite of 5-HT (useful for diagnosis).
 

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Not only pancreas cancer is associated with trousseau but also other GI mucin secreting tumors like Colorectal, Stomach and ovarian cancers.

Renal, Hemangioblastoma, Hepatocellular -> polycytemia through EPO.

Paraneoplastic pemphigus -> lympoprolifarative
 

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also paraneoplastic syndromes are associated with production of antibodies
like anti -yo in breast and ovary ca
anti hu and anti p/q antibodies in lung ca associated with cerebellar dysfunction
 
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