[achistikbenny]

During an experiment 500mg of both drug X and Y are simultaneously administered IV, the serum concentration of both drugs after bolus administration is 5 mg and 2.5mg respectively. Assuming no drug interactions. Which of the finding regarding the drug Y is compared with drug X?

A. decreased clearance
B. decreased half life
C. decreased volume of distribution
D. increased clearance
E. increased half life
F. increased volume of distribution

 

[drmodi44]

F??

f.increased volume of distribution

 

[tomymajor]

f.increased volume of distribution
because serum conc is inversely related to Vd

 

[ecgram]

yup i will go with F

as amount given is same volume is inversely related to the concentration

 

[ashishkabir]

Yup - I agree - F...

If equivalent amounts of two drugs are introduced IV there's no bioavailability issue so this implies that if serum concentrations are different then more of drug x is not absorbed into tissues and such.

We define this as volume of distribution - ie: the Vd for X is lower than the Vd for y or the Vd for y is greater than the Vd for x

The formula that everyone is talking about is:

Vd = D / C where Vd= volume of distribution, D is dose (500mg here) and C is serum concentration (5 mg for x) and (2.5 mg for y)

 

[achistikbenny]

yes the ans is F.Thanks for ur explanations

 

[silakan_isi]

Yeah,

it's F the best Answer thanks Guys . . ))

 

[DrewVestal]

yep its f.