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A 13yr old girl is brought to the emergency department by her father after he found her in semicomatose state with an empty bottle of antihistamine beside her bed. plasma diphenhydramine concentrations measured hourly for 6hr are shown.

Time plasma drug concentration (ng/ml)
1:00pm 240
2:00pm 202
3:00pm 170
4:00pm 143
5:00pm 120
6:00pm 101

Approximately how long after the first measurement(in hours)will take for this patient's plasma concentration to drop below 10ng/ml?

a.10
b.12
c.16
d.20
e.24
f. 30
g.38
 
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