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Why women have endometrial cancer in the menopause?
I believe that the have less estrogen!
In menopause, you still have some estrogen although it's reduced compared to its premenopausal levels.
The source of postmenopausal estrogen is the adrenal zona reticularis where DHEA is produced and then aromatized in ovarian stroma and fatty tissues to Estrone.
It's the effect of unopposed estrone (as no more progesterone from corpus letuem) that causes endometrial hyperplasia which is a precursor of endometrial carcinoma, the most common female genital cancer in the aging US population and the second killer after ovarian cancer.
 

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In menopause, you still have some estrogen although it's reduced compared to its premenopausal levels.
The source of postmenopausal estrogen is the adrenal zona reticularis where DHEA is produced and then aromatized in ovarian stroma and fatty tissues to Estrone.
It's the effect of unopposed estrone (as no more progesterone from corpus letuem) that causes endometrial hyperplasia which is a precursor of endometrial carcinoma, the most common female genital cancer in the aging US population and the second killer after ovarian cancer.
or it can be due to hormone replacement therapy and more estrogen in dat....:)
 

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the patient will be mostly an obese woman ..obesity is a high risk factor. adrenal androgens will b converted to estrogens.. and etiology of endometrial cancers is estrogen..
mc gynaecological cancer in post menopausal age is endometrial
mc cause of death by gynaecological cancer is ovarian cancer
mc overall cause of death is heart disease
and most common cancer is lung cancer
 

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In menopause, you still have some estrogen although it's reduced compared to its premenopausal levels.
The source of postmenopausal estrogen is the adrenal zona reticularis where DHEA is produced and then aromatized in ovarian stroma and fatty tissues to Estrone.
It's the effect of unopposed estrone (as no more progesterone from corpus letuem) that causes endometrial hyperplasia which is a precursor of endometrial carcinoma, the most common female genital cancer in the aging US population and the second killer after ovarian cancer.
thanks for explaining :)
 

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postmenopausal estrogen is produced mainly by ovaries and that estrogen leads to endometrial carcinoma in women
 

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it related to Early menarche or Late menopause. Post menopausal estrogen Estrogen cause endometrial carcinoma.
 
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