Prolonged PT, PTT, or Both

Prolonged PT is seen in factor VII deficiency, Vitamin K deficiency, Warfarin therapy, Liver disease, and Factor VII inhibitors.

Prolonged PTT is seen in von Willbrand, hemophilia A and B and C, Heparin therapy, and Antiphospholipid syndrome

Prolonged PT and PTT is seen in deficiencies of the final common pathway factors such as factor V, prothrombin, fibrinogen, or factor X. Also in Liver disease, DIC, and combined heparin and warfarin therapy.