[excellence]

A patient with manic depressive disorder is treated with lithium, which slows the turnover of inositol phosphates and the phosphatidyl inositol derivatives in cells. Which of the following protein kinases is most directly affected by this drug?

A. Protein kinase C
B. Receptor tyrosine kinase
C. Protein kinase G
D. Protein kinase A
E. Protein kinase M

the correct answer: A: protein kinase C
Can someone please explain why?

 

[CisternaChyli]

A patient with manic depressive disorder is treated with lithium, which slows the turnover of inositol phosphates and the phosphatidyl inositol derivatives in cells. Which of the following protein kinases is most directly affected by this drug?

A. Protein kinase C
B. Receptor tyrosine kinase
C. Protein kinase G
D. Protein kinase A
E. Protein kinase M

the correct answer: A: protein kinase C
Can someone please explain why?

go back to your section in FA or Kaplan on enzyme pathways. inositol Phosphate (IP3) is coupled with DAG. Protein Kinase C is part of this pathway.

Here is a visual representation: